Improvement of dilated cardiomyopathy with methylprednisolone in a patient with multiple fibrosclerosis.

Abstract

Multifocal fibrosclerosis is a rare syndrome of unknown cause that is characterized by fibrosis involving multiple organ systems. Definitive diagnosis can only be made based on biopsy findings. In this case, the biopsy specimen of the patient demonstrates pulmonary hyalinated granuloma or sclerosing mediastinitis. There are few reports of multiple fibrosclerosis with heart failure. Here, we reported a case of retroperitoneal fibrosis with massive mediastinal involvement extending to pleura and pericardium causing pleuro- pericardial effusion with dilated cardiomyopathy. Systolic dysfunction was improved and pericardial effusion disappeared with methylprednisolone treatment.

• Authors: Ibrahim Altun, Goksel Guz, Fatih Akin, Nuri Kose, Ilknur Altun, Zeki Yuksel Gunaydin, Cem Sahin
• Journal: International cardiovascular research journal (Int Cardiovasc Res J) Vol. 8 Issue 4 Pg. 178-80 (Dec 2014) ISSN: 2251-9130 [Print] Netherlands
• PMID: 25614863 (Publication Type: Case Reports)