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Definitive radiotherapy for primary vaginal cancer: correlation between treatment patterns and recurrence rate.

Abstract
The purpose of this study was to determine the outcomes and optimal practice patterns of definitive radiotherapy for primary vaginal cancer. Between 1993 and 2012, 49 patients were treated with definitive radiotherapy for primary vaginal cancer in three hospitals. Of these, 15 patients (31%) had clinically positive regional lymph node metastasis. A total of 34 patients (70%) received external beam radiotherapy with high-dose-rate brachytherapy (interstitial or intracavitary), and 8 (16%) (with small superficial Stage I tumors) were treated with local radiotherapy. The median follow-up was 33 months (range: 1-169 months). The 3-year overall survival (OS), disease-free survival (DFS), and loco-regional control (LRC) rates were 83%, 59% and 71%, respectively. In multivariate analysis, the histological type (P = 0.044) was significant risk factors for LRC. In Federation of Gynecology and Obstetrics (FIGO) Stage I cases, 3 of 8 patients (38%) who did not undergo prophylactic lymph node irradiation had lymph node recurrence, compared with 2 of 12 patients (17%) who underwent prophylactic pelvic irradiation. For Stage III-IV tumors, the local recurrence rate was 50% and the lymph node recurrence rate was 40%. Patients with FIGO Stage I/II or clinical Stage N1 had a higher recurrence rate with treatment using a single modality compared with the recurrence rate using combined modalities. In conclusion, our treatment outcomes for vaginal cancer were acceptable, but external beam radiotherapy with brachytherapy (interstitial or intracavitary) was needed regardless of FIGO stage. Improvement of treatment outcomes in cases of FIGO Stage III or IV remains a significant challenge.
AuthorsNaoyuki Kanayama, Fumiaki Isohashi, Yasuo Yoshioka, Sungjae Baek, Masashi Chatani, Tadayuki Kotsuma, Eiichi Tanaka, Ken Yoshida, Yuji Seo, Osamu Suzuki, Seiji Mabuchi, Yasuhiko Shiki, Keiji Tatsumi, Tadashi Kimura, Teruki Teshima, Kazuhiko Ogawa
JournalJournal of radiation research (J Radiat Res) Vol. 56 Issue 2 Pg. 346-53 (Mar 2015) ISSN: 1349-9157 [Electronic] England
PMID25614068 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

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