Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin.

Abstract

CONTEXT:

Salvia miltiorrhiza Bge. (Labiatae) has been widely used for treating diabetes for centuries. Salvianolic acid B (SalB) is the main bioactive component in Salvia miltiorrhiza; however, its antidiabetic activity and possible mechanism are not yet clear.

OBJECTIVE:

To investigate the effects of SalB on glycometabolism, lipid metabolism, insulin resistance, oxidative stress, and glycogen synthesis in type 2 diabetic rat model.

MATERIALS AND METHODS:

High-fat diet (HFD) and streptozotocin-induced diabetic rats were randomly divided into model group, SalB subgroups (50, 100, and 200 mg/kg), and rosiglitazone group.

RESULTS:

Compared with the model group, SalB (100 and 200 mg/kg) significantly decreased blood glucose (by 23.8 and 21.7%; p < 0.05 and p < 0.01) and insulin (by 31.3 and 26.6%; p < 0.05), and increased insulin sensitivity index (by 10.9 and 9.3%; p < 0.05). They also significantly decreased total cholesterol (by 24.9 and 27.9%; p < 0.01), low-density lipoprotein cholesterol (by 56.2 and 64.6%; p < 0.01), non-esterified fatty acids (by 32.1 and 37.9%; p < 0.01), hepatic glycogen (by 41.3 and 60.5%; p < 0.01), and muscle glycogen (by 33.2 and 38.6%; p < 0.05), and increased high-density lipoprotein cholesterol (by 50.0 and 61.4%; p < 0.05 and p < 0.01), which were originally altered by HFD and streptozotocin. In addition, SalB (200 mg/kg) markedly decreased triglyceride and malondialdehyde (by 31.5 and 29.0%; p < 0.05 and p < 0.01), and increased superoxide dismutase (by 56.6%; p < 0.01), which were originally altered by HFD and streptozotocin.

DISCUSSION AND CONCLUSION:

The results indicate that SalB can inhibit symptoms of diabetes mellitus in rats and these effects may partially be correlated with its insulin sensitivity, glycogen synthesis and antioxidant activities.

• Authors: Mingqing Huang, Peijian Wang, Shuyu Xu, Wen Xu, Wei Xu, Kedan Chu, Jinjian Lu
• Journal: Pharmaceutical biology (Pharm Biol) Vol. 53 Issue 7 Pg. 1058-65 (Jul 2015) ISSN: 1744-5116 [Electronic] England
• PMID: 25612777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzofurans
• Blood Glucose
• Drugs, Chinese Herbal
• Streptozocin
• salvianolic acid B

Topics

• Animals
• Benzofurans (isolation & purification, pharmacology, therapeutic use)
• Blood Glucose (drug effects, metabolism)
• Diabetes Mellitus, Type 2 (blood, chemically induced, drug therapy)
• Diet, High-Fat (adverse effects)
• Drugs, Chinese Herbal (isolation & purification, pharmacology, therapeutic use)
• Male
• Rats
• Rats, Sprague-Dawley
• Salvia miltiorrhiza
• Streptozocin (toxicity)