Abstract |
From Jan. 1979 to Nov. 1987, 38 patients with invasive mole and 5 patients of choriocarcinoma were primarily treated with methotrexate and citrovorum factor (MTX-CF) rescue. Thirty-two patients had non-metastatic disease (stage I) and 11 had metastatic disease (stage IIA in 5 cases, stage IIB in 3 cases and stage IIIA in 3 cases). Complete remission was achieved in 28 (87.5%) of 32 patients with non-metastatic disease and in 9 (81.8%) of 11 patients with metastatic disease. Six patients with MTX-CF resistant tumors subsequently achieved complete remission with intravenous infusion of KSM and/or AT 1258. All patients were followed up periodically, 22 of them have been followed up for over 2 years, the longest duration of follow-up being 7 years. Seven of the 14 patients with preserved uterus became pregnant after recovery. All children grew up normally.
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Authors | Y C Sha, J X Yu |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 24
Issue 6
Pg. 354-6, 382
(Nov 1989)
ISSN: 0529-567X [Print] China |
PMID | 2561092
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Choriocarcinoma
(drug therapy)
- Female
- Follow-Up Studies
- Humans
- Hydatidiform Mole, Invasive
(drug therapy)
- Leucovorin
(administration & dosage)
- Methotrexate
(administration & dosage)
- Middle Aged
- Pregnancy
- Uterine Neoplasms
(drug therapy)
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