| Abstract | Ciclosporin is clinically effective in a variety of inflammatory skin diseases. We have therefore studied the effects of the drug on cutaneous inflammation in mice. Ciclosporin inhibited the inflammatory response to 12-O-tetradecanoylphorbol-13-acetate (TPA) and to the contact sensitising agent oxazolone when applied topically to mouse skin. The drug had no effect on arachidonic acid-induced inflammation. The protein synthesis inhibitor cycloheximide showed a similar profile of activity. Ciclosporin, like actinomycin D but unlike cycloheximide, was only effective in inhibiting the inflammatory response to TPA if given 0.5 h before, but not 2 h, after TPA. These results suggest that the anti-inflammatory activity of ciclosporin in the skin is due to an effect on the production of proinflammatory proteins. |
| Authors | R J Griffiths, B E Wood, S Li, A Blackham
(Affiliation: Department of Pharmacology, Fisons plc Pharmaceutical Division, Loughborough, Leics., UK.)
|
| Journal | Skin pharmacology : the official journal of the Skin Pharmacology Society
(Skin Pharmacol)
Vol. 2
Issue 1
Pg. 30-7
( 1989)
ISSN: 1011-0283 SWITZERLAND |
| PMID | 2560651
(Publication Type: Journal Article)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Arachidonic Acids
- Cyclosporins
- Protein Synthesis Inhibitors
- Oxazolone
- Tetradecanoylphorbol Acetate
- Dactinomycin
- Arachidonic Acid
- Cycloheximide
- Peroxidase
|
| Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Arachidonic Acid
- Arachidonic Acids
(antagonists & inhibitors)
- Cycloheximide
(pharmacology)
- Cyclosporins
(pharmacology)
- Dactinomycin
(pharmacology)
- Dermatitis
(drug therapy, pathology)
- Female
- Hypersensitivity, Delayed
(drug therapy)
- Mice
- Mice, Inbred Strains
- Neutrophils
(enzymology, metabolism)
- Oxazolone
(antagonists & inhibitors)
- Peroxidase
(metabolism)
- Protein Synthesis Inhibitors
(pharmacology)
- Skin
(pathology)
- Tetradecanoylphorbol Acetate
(pharmacology)
|
