Abstract | INTRODUCTION: METHODS: One group was considered as control (n=6 eyes) then, corneal NV was induced in 30 New Zealand male rabbits (n=60 eyes) by placing 7.0 silk sutures at midstromal depth approximately1mm from the limbus. Fifteen rabbits with corneal NV were left without any treatment, and 15 rabbits were subjected to photodynamic therapy ( PDT) by intravenous injection with Verteporfin at a dose of 1.5 mg /Kg. Diode laser (660 nm) was applied after 15 minutes for 5 minutes with a power of 50 mW/cm2. All rabbits were successively followed up by slit lamp examination for periods of 1 day, 1, 2, 3 and 4 weeks. Three rabbits were selected and sacrificed weekly (n=6 eyes each) and the corneas were isolated for histopathological examination. RESULTS: The results of slit lamp examination indicated the gradual regression of the cornea neovascularization 4 weeks of PDT. Furthermore, regression of corneal neovascularization was documented clinically by decrease number and length of blood vessels and by histopathological examination. CONCLUSION:
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Authors | Aziza Ahmed Hassan, Dina Foad Ghoneim, Amr Abdelraheem El-Dib, Salwa Abdelkawi Ahmed, Ahmed Medhat Abdel-Salam |
Journal | Journal of lasers in medical sciences
(J Lasers Med Sci)
Vol. 4
Issue 3
Pg. 131-9
( 2013)
ISSN: 2008-9783 [Print] Iran |
PMID | 25606321
(Publication Type: Journal Article)
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