The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.

Abstract

The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.

• Authors: Yanqing Zang, Liping Zhang, Kiharu Igarashi, Changqing Yu
• Journal: Food & function (Food Funct) Vol. 6 Issue 3 Pg. 834-41 (Mar 2015) ISSN: 2042-650X [Electronic] England
• PMID: 25599885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Obesity Agents
• Glycated Hemoglobin A
• Glycosides
• Hypoglycemic Agents
• Hypolipidemic Agents
• Kaempferols
• Plant Extracts
• kaempferol

Topics

• Adiposity
• Animals
• Anti-Obesity Agents (analysis, chemistry, isolation & purification, therapeutic use)
• Diabetes Mellitus, Type 2 (complications, etiology, metabolism, prevention & control)
• Diet, High-Fat (adverse effects)
• Dietary Supplements (analysis)
• Glycated Hemoglobin (analysis)
• Glycosides (analysis, chemistry, isolation & purification, therapeutic use)
• Humans
• Hypertriglyceridemia (complications, etiology, metabolism, prevention & control)
• Hypoglycemic Agents (analysis, chemistry, isolation & purification, therapeutic use)
• Hypolipidemic Agents (analysis, chemistry, isolation & purification, therapeutic use)
• Insulin Resistance
• Kaempferols (analysis, chemistry, isolation & purification, therapeutic use)
• Lipid Metabolism
• Male
• Mice, Inbred C57BL
• Obesity (complications, etiology, metabolism, prevention & control)
• Plant Extracts (chemistry, isolation & purification, therapeutic use)
• Plant Leaves (chemistry, growth & development)
• Random Allocation
• Soybeans (chemistry, growth & development)