[Efficacy and safety of Longjintonglin Capsule for the treatment of type III prostatitis].

Abstract

OBJECTIVE:

To study the therapeutic effect and safety of Longjintonglin Capsule in the treatment of type III prostatitis (chronic prostatitis/chronic pelvic pain syndrome, CP/CPPS).

METHOD:

We selected 240 patients with type III prostatitis according to the diagnostic standards of the American National Institute of Health (NIH) and treated them with Longjintonglin Capsule orally 3 capsules once tid for 12 weeks. Based on the NIH chronic prostatitis symptom index (NIH-CPSI), traditional Chinese medicine (TCM) syndrome score, and leukocyte count in the expressed prostatic secretion (EPS), we evaluated the results of treatment.

RESULTS:

Totally 238 patients completed the treatment, including 108 IIIA and 120 III B prostatitis cases. Before and after 4, 8, and 12 weeks of treatment, the total NIH-CPSI scores were 23.12 ± 6.99, 18.22 ± 6.39, 14.12 ± 5.88, and 12.36 ± 6.04 (P < 0.01) in the IIIA prostatitis patients and 22.01 ± 6.28, 17.56 ± 5.89, 13.67 ± 5.18, and 11.45 ± 5.22 in the III prostatitis patients (P < 0.01), the TCM syndrome scores were 52.12 ± 13.08, 48.13 ± 12.11, 43.05 ± 11.19, and 40.78 ± 10. 59 in the former (P < 0.01) and 53.02 ± 12.12, 49.32 ± 12.78, 44.01 ± 11.79, and 39.67 ± 10.26 in the latter (P < 0.01), and the leukocyte counts were 26.09 ± 21.55, 23.02 ± 18.61, 18.25 ± 17.79, and 15.36 ± 16.38 in the IIIA cases (P < 0.01). Neither abnormalities in liver and renal function nor obvious adverse events were observed during the experiment.

CONCLUSION:

Longjintonglin Capsule, with its advantages of safety, effectiveness, and no obvious adverse reactions in the treatment of type III prostatitis, deserves to be recommended for clinical application.

• Authors: Xue-Jun Shang, Qiang Geng, Jian-Min Duan, De-Quan Zheng, Lei Xie, Jun Guo
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 20 Issue 12 Pg. 1109-12 (Dec 2014) ISSN: 1009-3591 [Print] China
• PMID: 25597179 (Publication Type: Journal Article)

Chemical References

• Capsules
• Drugs, Chinese Herbal

Topics

• Administration, Oral
• Adult
• Capsules
• Chronic Pain (drug therapy)
• Drug Administration Schedule
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Male
• Middle Aged
• Pelvic Pain (drug therapy)
• Phytotherapy
• Prostatitis (drug therapy)
• Syndrome