Abstract | AIMS/HYPOTHESIS: METHODS:
NNMT expression and plasma MNA were analysed in three groups of individuals: (1) 199 patients undergoing abdominal surgery; (2) 60 individuals on a 12-week exercise programme and (3) 55 patients on a two-step bariatric surgery programme. RESULTS: Patients with manifest type 2 diabetes have a significantly (approximately twofold) higher NNMT expression both in omental and subcutaneous WAT compared with controls. Notably, plasma MNA correlated significantly with WAT NNMT expression in patients with type 2 diabetes (women, r = 0.59, p < 0.001; men, r = 0.61, p < 0.001) but not in healthy control individuals. In insulin-resistant individuals, there was an inverse correlation between insulin sensitivity and plasma MNA (r = 0.44, p = 0.01) or adipose tissue NNMT mRNA (r = 0.64, p < 0.001). The latter association was confirmed in a second cohort (n = 60, r = 0.78, p < 0.001). Interventions improving insulin sensitivity--exercise and bariatric surgery--were associated with a significant (p < 0.001) reduction in WAT NNMT expression. Bariatric surgery was also associated with a significant decrease in plasma MNA. CONCLUSIONS/INTERPRETATION:
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Authors | Aimo Kannt, Anja Pfenninger, Lenore Teichert, Anke Tönjes, Arne Dietrich, Michael R Schön, Nora Klöting, Matthias Blüher |
Journal | Diabetologia
(Diabetologia)
Vol. 58
Issue 4
Pg. 799-808
(Apr 2015)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 25596852
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- RNA, Messenger
- Niacinamide
- NNMT protein, human
- Nicotinamide N-Methyltransferase
- N(1)-methylnicotinamide
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Topics |
- Adult
- Aged
- Bariatric Surgery
- Biomarkers
(blood)
- Case-Control Studies
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, diagnosis, physiopathology)
- Exercise Therapy
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Niacinamide
(analogs & derivatives, blood)
- Nicotinamide N-Methyltransferase
(genetics, metabolism)
- Obesity
(blood, diagnosis, therapy)
- RNA, Messenger
(genetics, metabolism)
- Subcutaneous Fat
(enzymology)
- Time Factors
- Treatment Outcome
- Young Adult
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