Abstract | BACKGROUND: Outbreaks of nosocomial infection due to carbapenem-resistant Enterobacteriaceae (CRE), mostly Klebsiella spp., have become a worldwide phenomenon. AIM: To investigate the risk factors for the acquisition of clonal multidrug-resistant Klebsiella oxytoca (MDRKO) producing the metallo-β-lactamase IMP-8 and hyperproducing chromosomal OXY-2 β-lactamase during a well-characterized outbreak, and to describe the clinical features of infections due to MDRKO. METHODS: A four-wave outbreak due to MDRKO occurred in the intensive care unit of a Spanish hospital between 2009 and 2011. The risk factors for acquisition of MDRKO during waves 1 and 2 (in which colonized patients served as the main reservoir for the epidemic strain) were analysed using a case-control study by Cox regression and logistic regression analysis. Clinical data and treatments of patients infected with MDRKO were also analysed. FINDINGS: For the study of risk factors, 26 cases and 45 controls were studied. None of the variables studied in the Cox regression analysis showed an association with MDRKO acquisition; time at risk was the only associated variable by logistic regression analysis. Colonization pressure was not associated with earlier acquisition. Overall, 14 patients were infected with MDRKO; ventilator-associated pneumonia (seven patients) was the most frequent type of infection. Monotherapy tended to be associated with higher mortality than combination therapy [60% (3/5) vs 16.6% (1/6); P = 0.07]. CONCLUSIONS: Time at risk was the most significant risk determinant for the acquisition of carbapenem-resistant Enterobacteriaceae (CRE) in this epidemiological context and should be included in any study of risk factors for the acquisition of multidrug-resistant bacteria. Combination therapy may be superior to monotherapy for the treatment of CRE infections.
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Authors | S Vergara-López, M C Domínguez, M C Conejo, Á Pascual, J Rodríguez-Baño |
Journal | The Journal of hospital infection
(J Hosp Infect)
Vol. 89
Issue 2
Pg. 123-31
(Feb 2015)
ISSN: 1532-2939 [Electronic] England |
PMID | 25595832
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- beta-Lactamases
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Topics |
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Case-Control Studies
- Cross Infection
(drug therapy, epidemiology, microbiology)
- Drug Therapy, Combination
- Female
- Humans
- Intensive Care Units
(statistics & numerical data)
- Klebsiella Infections
(drug therapy, epidemiology, microbiology)
- Klebsiella oxytoca
(enzymology, isolation & purification)
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Spain
(epidemiology)
- Time Factors
- beta-Lactam Resistance
- beta-Lactamases
(biosynthesis)
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