Abstract | BACKGROUND: MATERIALS AND METHODS: This prospective study was conducted at Postgraduate Institute of Medical Education and Research between January 2012 and March 2013. Fourteen patients (8 males, age 18-50 years) with acute OPC poisoning were included in the study based on the history and clinical features, documented decreased in plasma cholinesterase activity or presence of the OPC in gastric lavage/blood samples. The hormonal parameters were done at baseline, at the time of discharge and at three months of follow-up. RESULTS: A total of 14 patients out of 46 with the mean age of 30.1 ± 10.3 years were finally eligible for the study. Hormonal alterations at admission were similar to sick euhormonal syndrome. Overall 7 of them had nine hormonal deficits at three months of follow up, 4 having sub normal basal cortisol level and two each had low testosterone and growth hormone and only one had thyroxine deficiency. CONCLUSION: Acute organophosphate poisoning results in endocrine dysfunction akin to sick euhormonal syndrome. However, in a small subset of patients, varying level of hormonal insufficiency may occur either at admission or later. These observations need re-validation in a larger group of patients with specific OPC.
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Authors | Pinaki Dutta, Shruthi S Kamath, Ashish Bhalla, V N Shah, Anand Srinivasan, Prakamya Gupta, Surjit Singh |
Journal | Indian journal of endocrinology and metabolism
(Indian J Endocrinol Metab)
2015 Jan-Feb
Vol. 19
Issue 1
Pg. 116-23
ISSN: 2230-8210 [Print] India |
PMID | 25593838
(Publication Type: Journal Article)
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