Cinacalcet in pediatric and adolescent chronic kidney disease: a single-center experience.

Abstract

Cinacalcet, a calcimimetic drug, has been shown to be efficacious in adult chronic kidney disease (CKD) patients; however, it was not fully studied in pediatric CKD patients. We aimed at assessing the effect of cinacalcet on intact parathyroid hormone (iPTH) secretion in children with CKD-4/5 with iPTH consistently ≥ 300 pg/mL refractory to conventional treatment. This is a prospective cohort analysis of 28 children with uncontrolled hyper-parathyroidism secondary to stage 4 and 5 CKD admitted to a tertiary center during the period from April 2012 to April 2014. Twenty-eight patients with CKD-4/5 were assessed prospectively regarding bone biochemistry, renal ultrasonography, serum iPTH level, and medications. Patients were classified into 3 groups: group 1, 6 patients with CKD-4 on supplemental and supportive therapy; group 2, 6 patients with CKD-5 on hemodialysis and; group 3, 16 patients with CKD-5 on automated peritoneal dialysis. Patients were between the ages of 9 months and 18 years on commencing cinacalcet at doses of 0.5 to 1.5 mg/kg. All patients showed at least a 60% reduction in iPTH (60%-97%). Highly significant reduction in iPTH and serum alkaline phosphatase levels was detected post-cinacalcet. The serum calcium (Ca), phosphate (P), and Ca × P product were unaffected. Treatment was well tolerated with no hypophosphatemia, hypocalcemia, or other adverse effects almost in all patients. Cinacalcet use was proven safe for all pediatric and adolescent patients with CKD-4/5 during the study period, and at the same time most of the patients reached the suggested iPTH target values.

• Authors: Abdulla A Alharthi, Naglaa M Kamal, Mohamed W Abukhatwah, Laila M Sherief
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 2 Pg. e401 (Jan 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 25590845 (Publication Type: Journal Article)

Chemical References

• Calcimimetic Agents
• Naphthalenes
• Parathyroid Hormone
• Alkaline Phosphatase
• Cinacalcet

Topics

• Adolescent
• Alkaline Phosphatase (blood)
• Bone Density (drug effects)
• Calcimimetic Agents (administration & dosage, adverse effects)
• Child
• Child, Preschool
• Cinacalcet
• Drug Monitoring
• Female
• Humans
• Hyperparathyroidism, Secondary (blood, drug therapy, etiology)
• Infant
• Kidney (diagnostic imaging, physiopathology)
• Kidney Function Tests
• Male
• Naphthalenes (administration & dosage, adverse effects)
• Parathyroid Hormone (metabolism)
• Patient Acuity
• Practice Guidelines as Topic
• Prospective Studies
• Renal Dialysis (methods)
• Renal Insufficiency, Chronic (complications, diagnosis, physiopathology, therapy)
• Saudi Arabia
• Treatment Outcome
• Ultrasonography