Muramyl peptides confer hepatoprotection against murine viral hepatitis.

Abstract

The hepatoprotection induced by synthetic muramyl peptides was investigated using a model of lethal murine mouse hepatitis MHV-3 virus infection. MDP and a nonpyrogenic analog, Murametide, inhibited the steep elevation of serum transaminases induced by MHV-3 irrespective of whether the immunomodulators were administered before or after the infection. A significant proportion of MDP or Murametide-treated animals, in contrast to controls, survived the MHV-3 infection. The histopathological examination of the liver revealed marked necrosis of the hepatic parenchymal cells and infiltration of the inflammatory cells in controls but not in MDP-treated animals.

• Authors: K N Masihi, H Kröger, W Lange, L Chedid
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 11 Issue 8 Pg. 879-86 ( 1989) ISSN: 0192-0561 [Print] England
• PMID: 2559041 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Acetylmuramyl-Alanyl-Isoglutamine
• N-acetylmuramyl-alanylglutamine methyl ester
• Poly(ADP-ribose) Polymerases
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, pharmacology)
• Adjuvants, Immunologic (pharmacology)
• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Hepatitis, Viral, Animal (enzymology, pathology, prevention & control)
• Mice
• Murine hepatitis virus
• Poly(ADP-ribose) Polymerases (metabolism)