Abstract | BACKGROUND:
Olanzapine pamoate injection is an anti-psychotic depot to be administered intramuscularly once every 2-4 weeks. A post-injection syndrome may occur shortly after administration, resulting in an acute intoxication with olanzapine. CASE DESCRIPTION: A 42-year-old patient with a schizophrenic disorder lost consciousness 30 min after administration of olanzapine pamoate. He was admitted to a nearby hospital with tachycardia, hypotension, pin-point pupils and respiratory distress leading to reduced oxygen saturation. He was ventilated during one night and recovered within 2 days. CONCLUSION: A post-injection syndrome may develop after administration of olanzapine pamoate when the entire dose olanzapine is released at once from the muscle. Therefore, the patient should be observed for at least 3 hours after every injection. The risk of a post-injection syndrome and the necessary observation period should to be taken into account when deciding to start treatment with olanzapine pamoate depot.
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Authors | Erik B Wilms, Marijke T van der Velden, Fred H van Essen, Celine ten Brink |
Journal | Nederlands tijdschrift voor geneeskunde
(Ned Tijdschr Geneeskd)
Vol. 159
Pg. A7885
( 2014)
ISSN: 1876-8784 [Electronic] Netherlands |
Vernacular Title | Postinjectiesyndroom na depotinjectie met olanzapine. |
PMID | 25589277
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Benzodiazepines
- Olanzapine
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Topics |
- Adult
- Antipsychotic Agents
(administration & dosage, adverse effects)
- Benzodiazepines
(administration & dosage, adverse effects)
- Drug-Related Side Effects and Adverse Reactions
- Humans
- Injections, Intramuscular
(adverse effects)
- Male
- Olanzapine
- Schizophrenia
(drug therapy)
- Syndrome
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