[Post-injection syndrome after depot injection of olanzapine].

Olanzapine pamoate injection is an anti-psychotic depot to be administered intramuscularly once every 2-4 weeks. A post-injection syndrome may occur shortly after administration, resulting in an acute intoxication with olanzapine.
A 42-year-old patient with a schizophrenic disorder lost consciousness 30 min after administration of olanzapine pamoate. He was admitted to a nearby hospital with tachycardia, hypotension, pin-point pupils and respiratory distress leading to reduced oxygen saturation. He was ventilated during one night and recovered within 2 days.
A post-injection syndrome may develop after administration of olanzapine pamoate when the entire dose olanzapine is released at once from the muscle. Therefore, the patient should be observed for at least 3 hours after every injection. The risk of a post-injection syndrome and the necessary observation period should to be taken into account when deciding to start treatment with olanzapine pamoate depot.
AuthorsErik B Wilms, Marijke T van der Velden, Fred H van Essen, Celine ten Brink
JournalNederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 159 Pg. A7885 ( 2014) ISSN: 1876-8784 [Electronic] Netherlands
Vernacular TitlePostinjectiesyndroom na depotinjectie met olanzapine.
PMID25589277 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Benzodiazepines
  • olanzapine
  • Adult
  • Antipsychotic Agents (administration & dosage, adverse effects)
  • Benzodiazepines (administration & dosage, adverse effects)
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Injections, Intramuscular (adverse effects)
  • Male
  • Schizophrenia (drug therapy)
  • Syndrome

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