Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.

Abstract

Sleep disordered breathing (SDB) with recurrent apnea is a major health problem affecting several million adult men and women. Humans with SDB are prone to develop hypertension. Studies on rodents established that exposure to chronic intermittent hypoxia (CIH) alone is sufficient to induce hypertension similar to that seen in patients with SDB. Available evidence from studies on experimental animals suggests that catecholamines secreted from adrenal medulla (AM), an end-organ of the sympathetic nervous system is a major contributor to CIH-induced hypertension. In this article, we present an overview of our current understanding on how CIH reconfigures AM function and highlight recent findings on the underlying cellular and molecular mechanisms.

• Authors: Ganesh K Kumar, Jayasri Nanduri, Ying-Jie Peng, Nanduri R Prabhakar
• Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol) Vol. 209 Pg. 115-9 (Apr 2015) ISSN: 1878-1519 [Electronic] Netherlands
• PMID: 25583660 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Catecholamines
• Hypoxia-Inducible Factor 1, alpha Subunit
• Reactive Oxygen Species

Topics

• Adrenal Medulla (metabolism)
• Animals
• Catecholamines (metabolism)
• Humans
• Hypoxia (metabolism)
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• Reactive Oxygen Species (metabolism)