Effect of continuous positive airway pressure on insulin growth factor-1 in patients with obstructive sleep apnea: a meta-analysis.

Abstract

OBJECTIVE:

Obstructive sleep apnea (OSA) has been recognized as being associated with low level of insulin growth factor-1 (IGF-1). However, the impact of OSA treatment using continuous positive airway pressure (CPAP) on IGF-1 remains controversial. We performed a meta-analysis to determine whether effective CPAP therapy could increase IGF-1 levels.

DESIGN:

Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before September 2014. Information on characteristics of subjects, study design and pre- and post-CPAP treatment of serum IGF-1 was extracted for analysis. Standardized mean difference (SMD) was used to analyze the summary estimates for CPAP therapy.

RESULTS:

Six articles with 168 patients were included in this meta-analysis, including five observational studies and one randomized controlled study. The meta-analysis showed that CPAP was associated with a statistically significant increase in IGF-1 in OSA patients (SMD=-0.436, 95% confidence interval=-0.653 to -0.218, P=0.000).

CONCLUSIONS:

This meta-analysis suggested that CPAP therapy was associated with an increase in IGF-1 in patients with OSA. Further large-scale, well-designed interventional investigations are needed to clarify this issue.

• Authors: Li-Da Chen, Li Lin, Jie-Feng Huang, Xiao Chen, Qiao-Zhen Xu, Jian-Nan Liu
• Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 25 Issue 2 Pg. 75-9 (Apr 2015) ISSN: 1532-2238 [Electronic] Scotland
• PMID: 25582879 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Insulin-Like Growth Factor I

Topics

• Adult
• Aged
• Continuous Positive Airway Pressure
• Female
• Humans
• Insulin-Like Growth Factor I (metabolism)
• Male
• Middle Aged
• Observational Studies as Topic
• Randomized Controlled Trials as Topic
• Sleep Apnea, Obstructive (blood, epidemiology, therapy)