Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study.

Abstract

This prospective study sought to identify the potential reversibility of oxaliplatin-induced peripheral neuropathy (OXAIPN) by following-up its long-term course 2 years after discontinuation of oxaliplatin (OXA)-based chemotherapy. Participants were 91 colorectal cancer patients treated with OXA-based chemotherapy. Neurological assessment, clinical Total Neuropathy Score© (TNSc©) and nerve conduction studies were performed at baseline (T0), the end of chemotherapy (T1) and 2 years (T2) after discontinuation of chemotherapy. A total of 73 of 91 (80%) patients experienced OXAIPN at T1. At a median follow-up of 25 months, persistence of chronic OXAIPN was present in 61 of 73 patients (84%) and complete resolution was present in 12 patients (17%). Longitudinal comparison of TNSc© values between T1 and T2 revealed that the overall severity of OXAIPN in those 61 patients significantly decreased over time. Median TNSc© values were nine (range: 2-15) at T1 vs. four (range: 2-12) at T2 (P < 0.001). Likewise, sensory nerve conduction measures at T2 significantly improved in all sensory nerves tested, compared with T1. Severity of OXAIPN at T2 was significantly associated (P < 0.001) with high severity of OXAIPN at T1. In conclusion, persistence of OXAIPN beyond 2 years after finishing chemotherapy is common. Clinical and neurophysiological improvement is observed, although recovery is often incomplete.

• Authors: Chiara Briani, Andreas A Argyriou, Cristina Izquierdo, Roser Velasco, Marta Campagnolo, Paola Alberti, Barbara Frigeni, Mario Cacciavillani, Francesca Bergamo, Diego Cortinovis, Marina Cazzaniga, Jordi Bruna, Guido Cavaletti, Haralabos P Kalofonos
• Journal: Journal of the peripheral nervous system : JPNS (J Peripher Nerv Syst) Vol. 19 Issue 4 Pg. 299-306 (Dec 2014) ISSN: 1529-8027 [Electronic] United States
• PMID: 25582667 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Peripheral Nerve Society.

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Oxaloacetates
• Oxaliplatin
• Deoxycytidine
• Capecitabine
• Leucovorin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Agents (adverse effects)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Capecitabine
• Colorectal Neoplasms (drug therapy)
• Deoxycytidine (adverse effects, analogs & derivatives)
• Disease Progression
• Female
• Fluorouracil (adverse effects, analogs & derivatives)
• Follow-Up Studies
• Humans
• Leucovorin (adverse effects)
• Male
• Middle Aged
• Neurotoxicity Syndromes (epidemiology)
• Organoplatinum Compounds (adverse effects)
• Oxaliplatin
• Oxaloacetates
• Peripheral Nervous System Diseases (chemically induced, epidemiology, physiopathology)
• Prospective Studies
• Recovery of Function