CLIC1 a novel biomarker of intraperitoneal metastasis in serous epithelial ovarian cancer.

Abstract

Early diagnosis of intraperitoneal metastasis is a pivot for survival of patients with serous epithelial ovarian cancers (SEOC). However, to date, there is lack of efficient molecular biomarker for early metastasis of SEOC. Here, we found that the expression of chloride intracellular channel 1 (CLIC1) is highly correlative with intraperitoneal metastasis. There is very low expression of CLIC1 in normal ovaries (NO), benign ovarian tumor (BOT), and primary ovarian cancer without metastasis (POCNM); but its expression is remarkably high in primary ovarian cancer with metastasis (POCM) omentum and peritoneal metastasis. Furthermore, for clinic prediction of intraperitoneal metastasis of SEOC, the sensitivity and specificity of CLIC1 overexpression were 97.4 and 88.1 %, respectively. Collectively, CLIC1 may be a potential sensitive and specific molecular biomarker for early diagnose for SEOC metastasis.

• Authors: Yuguang Ye, Mingzhu Yin, Bihui Huang, Yaqi Wang, Xia Li, Ge Lou
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 6 Pg. 4175-9 (Jun 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25582317 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CLIC1 protein, human
• Chloride Channels

Topics

• Adult
• Aged
• Biomarkers, Tumor (biosynthesis, genetics)
• Carcinoma, Ovarian Epithelial
• Chloride Channels (biosynthesis, genetics)
• Cystadenocarcinoma, Serous (diagnosis, genetics, pathology)
• Early Detection of Cancer
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Middle Aged
• Neoplasm Staging
• Neoplasms, Glandular and Epithelial (diagnosis, genetics, pathology)
• Ovarian Neoplasms (diagnosis, genetics, pathology)
• Peritoneal Neoplasms (diagnosis, genetics, pathology, secondary)