Studies on inhibitors of skin tumor promotion, VI. Inhibitory effects of quinones on Epstein-Barr virus activation.

Abstract

To search for possible antitumor promoters, we carried out a primary screening of fifty-one quinones (anthraquinones, naphthoquinones, azaanthraquinones, and azafluorenones) and related compounds, using their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these quinones, notably 5-hydroxy-1,2-methylenedioxy-anthraquinone [9], shikonin [29], 2-acetylfuranonaphthoquinone [32], 5,8-dihydroxycleistopholine [37], and 5,8-dihydroxy-2-methyl-1-azaanthraquinone [45], were observed to significantly inhibit the EBV-EA activation at low doses. The position and number of hydroxyl groups on phenyl rings of these quinones affected the inhibitory activity on EBV-EA activation. The investigation indicates that 9, 29, 32, 37, and 45 might be valuable anti-tumor promoters.

• Authors: T Konoshima, M Kozuka, J Koyama, T Okatani, K Tagahara, H Tokuda
• Journal: Journal of natural products (J Nat Prod) 1989 Sep-Oct Vol. 52 Issue 5 Pg. 987-95 ISSN: 0163-3864 [Print] United States
• PMID: 2558164 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Quinones
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Antineoplastic Agents, Phytogenic (metabolism, pharmacology)
• Drug Screening Assays, Antitumor
• Female
• Herpesvirus 4, Human (drug effects, physiology)
• Magnetic Resonance Spectroscopy
• Mice
• Mice, Inbred ICR
• Quinones (pharmacology)
• Structure-Activity Relationship
• Tetradecanoylphorbol Acetate (metabolism)
• Tumor Cells, Cultured
• Virus Activation (drug effects)