HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study.

AbstractOBJECTIVE:
To investigate maternal and fetal outcome in hyperemesis gravidarum comparing enteral tube feeding of the mothers with other fluid/nutrition regimens.
DESIGN:
Retrospective hospital-based cohort.
SETTING:
University hospital, Norway.
SAMPLE:
All 558 women treated for hyperemesis gravidarum 2002-2011; 273 received water/electrolytes intravenously, 177 received nutritional supplements by peripheral line, 107 received enteral feeding by gastroscopically positioned nasojejunal tube and 10 received total parenteral nutrition.
METHODS:
Different fluid/nutritional groups were compared by chi-squared or non-parametric tests. The influence (odds ratio) of nutritional regimens on having small-for-gestational-age infants was evaluated by binary logistic regression.
MAIN OUTCOME MEASURES:
Maternal weight gain during hospitalization and pregnancy, birthweight and gestational age at delivery.
RESULTS:
Women receiving enteral nutrition had significantly greater weight loss on admission (median 5.0 kg) and at start of nutrition (5.5 kg) than the other treatment groups (4.0 kg) (p < 0.001). Enteral nutrition was administered for up to 41 days (median 5 days) during hospitalization, leading to 0.8 kg weight gain (95% CI 0.5-1.0, p = 0.005). The tube-fed women achieved similar weight gain during pregnancy and experienced similar incidence of preterm birth or small-for-gestational age compared with the other treatment groups. Women with <7 kg total weight gain had increased risk of birthweight <2500 g and small-for-gestational-age infants (odds ratio 3.68, 95% CI 1.89-7.18, p < 0.001). The nutritional regimen used was not an independent risk factor.
CONCLUSION:
Compared with other fluid/nutrition regimens, enteral tube feeding for women affected by severe hyperemesis gravidarum is associated with adequate maternal weight gain and favorable pregnancy outcomes.
AuthorsGuro Stokke, Bente L Gjelsvik, Katrine T Flaatten, Elisabeth Birkeland, Hans Flaatten, Jone Trovik
JournalActa obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 94 Issue 4 Pg. 359-67 (Apr 2015) ISSN: 1600-0412 [Electronic] United States
PMID25581215 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
Copyright© 2015 Nordic Federation of Societies of Obstetrics and Gynecology.
Topics
  • Adult
  • Birth Weight
  • Cohort Studies
  • Combined Modality Therapy
  • Enteral Nutrition (methods)
  • Female
  • Fetal Growth Retardation (etiology, prevention & control)
  • Fluid Therapy
  • Gestational Age
  • Humans
  • Hyperemesis Gravidarum (therapy)
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Intubation, Gastrointestinal
  • Logistic Models
  • Odds Ratio
  • Parenteral Nutrition, Total
  • Pregnancy
  • Premature Birth (etiology, prevention & control)
  • Retrospective Studies
  • Treatment Outcome
  • Weight Gain

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: