Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice.

Abstract

BACKGROUND:

Pogostemon benghalensis has been used traditionally as anticancer in India.

AIM OF THE STUDY:

The present study was undertaken to investigate the antitumor activity of hydroethanolic extract of P. benghalensis (HEEPB) and aqueous extract of P. benghalensis (AEPB) on ehrlich ascites carcinoma (EAC) tumor bearing mice.

MATERIALS AND METHODS:

For antitumor effect, treatments with HEEPB and AEPB at doses of 250 mg/kg and 500 mg/kg/day orally were started after 24 h of intraperitoneal inoculation of EAC cells. After the treatment period, median survival time (MST), hematological parameters and solid tumor volume were used to evaluate antitumor activity of the extracts.

RESULTS:

Both, HEEPB and AEPB, have increased MST (P<0.05), reduced solid tumor volume (P<0.05) and normalized hematological parameters (P<0.05) significantly.

CONCLUSION:

As HEEPB and AEPB were effective in reducing the severity of morphological and biochemical parameters induced by EAC cells, this study justifies the traditional use of this plant in cancer.

• Authors: Manish S Patel, Bhavesh V Antala, Ena Dowerah, Raju Senthilkumar, Mangala Lahkar
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 10 Issue 4 Pg. 1071-5 ( 2014) ISSN: 1998-4138 [Electronic] India
• PMID: 25579556 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Antioxidants
• Plant Extracts
• Ethanol

Topics

• Administration, Oral
• Animals
• Antineoplastic Agents, Phytogenic (chemistry)
• Antioxidants (metabolism)
• Apiaceae (chemistry)
• Carcinoma (drug therapy)
• Carcinoma, Ehrlich Tumor (drug therapy)
• Diffusion
• Drug Screening Assays, Antitumor
• Ethanol
• Female
• India
• Mice
• Neoplasm Transplantation
• Phytotherapy
• Plant Extracts (chemistry)
• Plant Leaves (chemistry)