HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity.

AbstractPURPOSE:
In an effort to prepare an oral dosage form for poorly bioavailable anti-cancer agents, we have incorporated spray drying using a customized spray gun generating enteric coated Self-emulsifying drug delivery systems. The objective of this study was to design and evaluate pharmacokinetics and pharmacodynamic characteristics of Spray BIO-Max DIM-P (SB DIM-P).
METHODS:
SB DIM-P was prepared and optimized based on physico-chemical characteristics using design of experiment (DOE-Vr 8.0) software. Pharmacokinetic parameters in dogs and rats were evaluated and analyzed using Winonlin. Anti-tumor activity was carried out in orthotopic and metastatic lung tumor models using size M capsules in mice.
RESULTS:
Based on the optimization using DOE analysis of SB DIM-P characteristics, formulations were selected for further investigation. Pharmacokinetic studies showed a 30% increase in oral bioavailability in rats and ~2.9 times more bioavailability of SB DIM-P compare to solution in dogs. SB DIM-P showed ~20-25% more tumor volume/weight reduction in H1650 metastatic tumor model and ~25-30% tumor volume/weight reduction in A549 orthotopic tumor model compared to DIM-P solution.
CONCLUSIONS:
Our studies demonstrate the potential application of spray dried enteric coated self-emulsifying delivery system (SB DIM-P) to enhances oral absorption and efficacy of DIM-P in lung tumor models.
AuthorsApurva R Patel, Chandraiah Godugu, Heather Wilson, Stephen Safe, Mandip Singh
JournalPharmaceutical research (Pharm Res) Vol. 32 Issue 7 Pg. 2292-300 (Jul 2015) ISSN: 1573-904X [Electronic] United States
PMID25576245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Emulsions
  • Indoles
Topics
  • Administration, Oral
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics, therapeutic use)
  • Biological Availability
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical
  • Dogs
  • Emulsions
  • Humans
  • Indoles (administration & dosage, chemistry, pharmacokinetics, therapeutic use)
  • Injections, Intravenous
  • Lung Neoplasms (drug therapy, metabolism, pathology)
  • Male
  • Mice, Nude
  • Neoplasm Metastasis
  • Rats, Sprague-Dawley
  • Xenograft Model Antitumor Assays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: