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HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III.

Abstract
The Alu family of repeated sequences is transcribed by both RNA polymerase II and RNA polymerase III. In cells infected with HSV, transcription by polymerase III increases while transcription by polymerase II decreases. By using virus strains carrying mutations in the genes encoding individual regulatory proteins, we have shown that this effect is dependent upon the immediate-early protein ICP27 and occurs by a process distinct from those which regulate viral gene expression. This is the first example of increased transcription of endogenous cellular sequences by RNA polymerase III during infection with a DNA virus.
AuthorsK L Jang, D S Latchman
JournalFEBS letters (FEBS Lett) Vol. 258 Issue 2 Pg. 255-8 (Dec 04 1989) ISSN: 0014-5793 [Print] England
PMID2557237 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • RNA, Neoplasm
  • RNA Polymerase II
  • DNA-Directed RNA Polymerases
  • RNA Polymerase III
Topics
  • Cell Nucleus (metabolism)
  • Cell Transformation, Viral
  • DNA-Directed RNA Polymerases (metabolism)
  • Gene Expression Regulation, Viral
  • HeLa Cells (metabolism)
  • Humans
  • RNA Polymerase II (metabolism)
  • RNA Polymerase III (metabolism)
  • RNA, Neoplasm (genetics, isolation & purification)
  • Repetitive Sequences, Nucleic Acid
  • Simplexvirus (genetics)
  • Transcription, Genetic

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