Abstract | OBJECTIVE: To identify the association between the insertion/deletion polymorphism of interleukin- 1A gene (IL1A) and the susceptibility of prostate cancer (PCA). METHODS: We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/ deletion polymorphism (rs3783553) in 3'-UTR of IL1A gene was genotyped by PCR-RFLP method. RESULTS: The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (P<0. 001, OR=O. 48, 95%CI: 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0. 001,OR=0. 56,95% CI: 0. 40-0. 79). CONCLUSION:
TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.
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Authors | Hong Liao, Lin Zhang, Peng Cheng, Yan Pu, Yi Wu, Zeng Li, Ying-ming Xiao, Sheng-ke' Yang |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 45
Issue 6
Pg. 956-9
(Nov 2014)
ISSN: 1672-173X [Print] China |
PMID | 25571723
(Publication Type: Journal Article)
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Chemical References |
- 3' Untranslated Regions
- IL1A protein, human
- Interleukin-1alpha
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Topics |
- 3' Untranslated Regions
- Alleles
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- INDEL Mutation
- Interleukin-1alpha
(genetics)
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Prostatic Neoplasms
(genetics)
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