Does casein phosphopeptid amorphous calcium phosphate provide remineralization on white spot lesions and inhibition of Streptococcus mutans?

Abstract

OBJECTIVE:

The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization.

STUDY DESIGN:

The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis.

RESULTS:

DIAGNOdent measurements were increased by time (p = 0.002) in control group and no statistically significant diference (p = 0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period.

CONCLUSIONS:

These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.

• Authors: Arzu Aykut-Yetkiner, Nazan Kara, Mustafa Ateş, Nazan Ersin, Fahinur Ertuğrul
• Journal: The Journal of clinical pediatric dentistry (J Clin Pediatr Dent) Vol. 38 Issue 4 Pg. 302-6 ( 2014) ISSN: 1053-4628 [Print] Singapore
• PMID: 25571679 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cariostatic Agents
• Caseins
• Toothpastes
• casein phosphopeptide-amorphous calcium phosphate nanocomplex
• Fluorides

Topics

• Adolescent
• Bacterial Load (drug effects)
• Cariostatic Agents (therapeutic use)
• Caseins (therapeutic use)
• Dental Caries (diagnosis, drug therapy, microbiology)
• Female
• Fluorides (therapeutic use)
• Follow-Up Studies
• Humans
• Hydrogen-Ion Concentration
• Lasers
• Male
• Saliva (metabolism, microbiology)
• Secretory Rate (physiology)
• Streptococcus mutans (drug effects)
• Tooth Remineralization (methods)
• Toothpastes (therapeutic use)