Long-term survival following pancreatectomy and s-1 chemotherapy for pancreatic acinar cell carcinoma with peritoneal dissemination: a case report and literature review.

Abstract

Current case is the third report of S-1 chemotherapy against acinar cell carcinoma (ACC) of pancreas, and our patient has achieved the longest reported recurrence-free survival, longer than 6 years, despite the presence of disseminated nodules at laparotomy.A 77-year-old man presented with abdominal discomfort. Computed tomography showed a low-density tumor in the pancreas tail and the patient was referred for surgery. A 3-cm sized pancreatic tumor, with localized disseminated nodules, was detected on laparotomy. Distal pancreatectomy with concomitant resection of disseminated nodules was performed, and histopathological examination revealed an ACC. Oral S-1 chemotherapy was administered postsurgery, and the patient showed no sign of recurrence during 73 months of follow-up. This is the first report of long-term survivor of pancreatic ACC with peritoneal dissemination, following pancreatectomy and S-1 chemotherapy.Current case suggests a beneficial effect of S-1 chemotherapy in cases of ACC.

• Authors: Tatsuaki Sumiyoshi, Yasuo Shima, Takehiro Okabayashi, Akihito Kozuki, Jun Iwata, Yuichi Saisaka, Teppei Tokumaru, Toshio Nakamura, Sojiro Morita
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 1 Pg. e378 (Jan 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 25569665 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Carcinoma, Acinar Cell (drug therapy, pathology, surgery)
• Drug Combinations
• Humans
• Male
• Oxonic Acid (therapeutic use)
• Pancreatic Neoplasms (drug therapy, pathology, surgery)
• Peritoneum (pathology)
• Tegafur (therapeutic use)