Abstract | BACKGROUND: METHODS: We retrospectively reviewed all histologically proven intraosseous atypical chondroid tumors or chondrosarcomas in our prospective nationwide Dutch tertiary referral multiple osteochondromas database. Demographic, clinical, radiographic, histological, and genetic data were recorded. The institutional medical ethics review board approved the study. RESULTS: From 195 adult patients, seven (3.6%) were identified with intraosseous atypical chondroid tumor or chondrosarcoma World Health Organization grade 1 and had a mean age of forty-two years; five of these patients were male. In all cases, radiographic and genetic findings were consistent with multiple osteochondromas, not metachondromatosis; three patients had an exostosin-1 mutation, four patients had an exostosin-2 mutation, and no patients had a protein tyrosine phosphatase, non-receptor type 11 mutation. Six patients underwent successful operative treatment without complications or recurrences after a mean follow-up duration of forty-eight months (range, twelve to 144 months). One patient was scheduled for surgery after biopsy and histologic confirmation. Of the seven patients, five (71%) also developed a peripheral chondrosarcoma in a known osteochondroma during the study period. CONCLUSIONS:
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Authors | Annemarie L Goud, Wim Wuyts, Johannes Bessems, Jos Bramer, Henk Jan van der Woude, John Ham |
Journal | The Journal of bone and joint surgery. American volume
(J Bone Joint Surg Am)
Vol. 97
Issue 1
Pg. 24-31
(Jan 07 2015)
ISSN: 1535-1386 [Electronic] United States |
PMID | 25568391
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Chondroma
(complications, diagnosis, surgery)
- Chondrosarcoma
(complications, diagnosis, surgery)
- Databases, Factual
- Exostoses, Multiple Hereditary
(complications, diagnosis, genetics, surgery)
- Female
- Humans
- Male
- Middle Aged
- Netherlands
- Young Adult
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