Abstract | PURPOSE: METHODS: A total of 139 male nondiabetic patients with OSA were recruited for participation in the study. Serum AGE levels were examined using an enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR). RESULTS: There was a significant correlation between serum AGEs and the apnea-hypopnea index (AHI) (r = 0.281, p = 0.014), duration of SaO₂ < 90% (r = 0.267, p = 0.018), minimum SaO₂ (r = -0.188, p = 0.046), high-sensitivity C-reactive protein ( hsCRP) (r = 0.274, p = 0.012), and HOMA-IR (r = 0.303, p < 0.001). Multiple regression analysis showed that serum AGEs (p = 0.011), AHI (p = 0.024), waist circumference (p = 0.040), and hsCRP (p = 0.046) were independently associated with HOMA-IR (R(2) = 0.392). In addition, the strength of the correlation between serum AGEs and HOMA-IR was related to the severity of OSA. CONCLUSIONS: The present study indicated that serum AGE levels were associated with insulin resistance in male nondiabetic patients with OSA. These findings suggest that AGEs may play a role in insulin resistance in OSA and may also be a biomarker for patients with OSA with high risk of developing type 2 diabetes.
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Authors | Ji-xiong Xu, Wei Cai, Jian-fang Sun, Wei-jian Liao, Ying Liu, Jun-ren Xiao, Ling-yan Zhu, Jian-ying Liu, Wei Zhang |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 19
Issue 3
Pg. 827-33
(Sep 2015)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 25566941
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycation End Products, Advanced
- Oxygen
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Topics |
- Adult
- Enzyme-Linked Immunosorbent Assay
- Female
- Glycation End Products, Advanced
(blood)
- Humans
- Insulin Resistance
(physiology)
- Male
- Middle Aged
- Oxygen
(blood)
- Polysomnography
- Sleep Apnea, Obstructive
(physiopathology)
- Sleep Stages
(physiology)
- Statistics as Topic
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