[Treatment of adenomyosis patients by bushen huoxue sanyu decoction: a clinical study].

Abstract

OBJECTIVE:

To observe the clinical efficacy of Bushen Huoxue Sanyu Decoction (BHSD) in treatment of adenomyosis (AM) patients.

METHODS:

Seventy AM patients of Shen deficiency blood stasis syndrome (SDBSS) were randomly assigned to two groups, the CM treatment group (50 cases) and the Mirena group (20 cases). Patients in the CM treatment group were treated with BHSD, one dose per day. Levonorgestrel intrauterine system (Mirena) was placed in the uterine cavity of those in the Mirena group. The therapeutic course for all was 3 months. Changes of dysmenorrhea, menstrual quantity, SDBSS, CM syndrome, uterine volume, and serum CA125 levels were observed before and after treatment.

RESULTS:

Compared with before treatment in the same group, scores for dysmenorrhea integral, scores for menstrual quantity, scores for SDBSS, and scores for CM syndrome all decreased in the two groups after treatment (P < 0.01). Compared with before treatment in the same group, the uterine volume was reduced after treatment in the two groups (P < 0.05) and serum carbohydrate antigen CA125 levels decreased between the two groups (P < 0.05, P < 0.01). Compared with the Mirena group, scores for dysmenorrhea integral increased and scores for SDBSS decreased in the CM treatment group (P < 0.01, P < 0.05). There was no statistical difference in the uterine volume or serum carbohydrate antigen CA125 levels (P > 0.05).

CONCLUSIONS:

BHSD could effectively alleviate main symptoms of AM patients of QSBSS such as dysmenorrhea, profuse menstrual blood volume, and increased uterine volume, and lower scores for QSBSS and the total score for CM syndrome.

• Authors: Chen Cheng, Tao Gui, Mei-hua Huang, Li Zhu, Xiao-ping Ma, Ai-hua Xun, Gui-ping Wan
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 34 Issue 11 Pg. 1302-5 (Nov 2014) ISSN: 1003-5370 [Print] China
• PMID: 25566618 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• bushen huoxue
• Levonorgestrel

Topics

• Adenomyosis (drug therapy)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Dysmenorrhea
• Female
• Humans
• Levonorgestrel (therapeutic use)