Humalog Mix 75/25
insulin analog is widely used in the People's Republic of China to treat
type 2 diabetes mellitus, but the
Humalog Mix 50/50 analog is not as yet widely used or assessed. The purpose of this 12-week, parallel-group, randomized, treat-to-target study was to evaluate the difference in clinical efficacy, safety, and outcome of treatment between
Humalog Mix 50/50 and
Humalog Mix 75/25 analogs in Chinese patients with
type 2 diabetes mellitus. In total, 146
insulin-naïve patients with
type 2 diabetes mellitus and aged 18-75 years were randomized and treated twice a day with either
Humalog Mix 50/50 (group A) or
Humalog Mix 75/25 (group B). We monitored levels of fasting
blood glucose, 2-hour postprandial
blood glucose, and
glycosylated hemoglobin (HbA1c) in patients in both groups prior to and 3 months post treatment, the average time to achieve target
blood glucose level, and frequency of
hypoglycemic episodes during treatment. We found that group A showed better
glycemic control as per fasting
blood glucose and 2-hour postprandial
blood glucose than group B. Moreover, HbA1c levels in group A (5.5%±1.4%) were lower by 1.0%±0.1% (P<0.05) compared with those in group B (6.5%±1.5%). The time to achieve
glucose control was shorter (P<0.05) in group A (12.6±3.6 days) than in group B (22.3±4.7 days). Regarding safety, no significant adverse events or severe
hypoglycemia on treatment was observed in either group. Additionally, the 1:1 ratio of
Humalog Mix 50/50 showed a trend towards fewer episodes of nocturnal
hypoglycemia. Thus, compared with
Humalog Mix 75/25, the high-proportion premix
insulin analog,
Humalog Mix 50/50 showed better
glycemic control, achieved target
blood glucose levels more rapidly and without an increase in
hypoglycemic episodes in Chinese type 2 diabetic individuals and is recommended for use in clinical practice.