HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lower response to early T-cell-dependent vaccination after neurotrauma or neurosurgery in adults.

AbstractBACKGROUND:
Recent international guidelines recommend vaccination with a 13-valent pneumococcal conjugate vaccine to reduce the risk of meningitis after neurotrauma with cerebrospinal fluid leak. The antibody response and optimal time point for vaccination have not been established and because the risk of meningitis is at the highest shortly after trauma, early vaccination is preferable. This study aimed to investigate the antibody response and to ensure that central nervous system injury-induced immunodepression did not affect the response to a T-cell-dependent conjugate vaccine when administered shortly after the injury.
METHODS:
So as not to interfere with routine pneumococcal vaccination, a conjugate vaccine against Haemophilus influenza type b (Hib) was chosen for the study. Thirty-three patients with basilar skull fracture and 23 patients undergoing transsphenoidal pituitary gland surgery were vaccinated within 10 days after trauma/surgery and 29 control patients at least three weeks after trauma/surgery. Sera were collected pre- and post-vaccination for analysis of anti-Hib concentration.
RESULTS:
Four patients with post-vaccination target antibody concentration before vaccination were excluded from analysis. In the neurotrauma and neurosurgery groups 10/32 (31%) and 5/20 (25%) patients, respectively, were non-responders compared with 3/29 (10%) in the control group. Log10 anti-Hib concentrations in the neurotrauma, neurosurgery and control groups were 1.52 ± 0.15, 1.38 ± 0.15 and 1.81 ± 0.12 μg/ml, respectively.
CONCLUSIONS:
The majority of the patients responded to vaccination. However, the number of responders was significantly decreased and antibody concentration significantly lower in patients vaccinated early after the trauma/surgery. Investigation of the pneumococcal conjugate vaccine response in neurotrauma patients is therefore urgent.
AuthorsAnna Ljunghill Hedberg, Karlis Pauksens, Elisabeth Ronne-Engström, Maria Lundberg, Björn Johansson, Helena Käyhty, Jan Sjölin
JournalThe Journal of infection (J Infect) Vol. 70 Issue 6 Pg. 577-84 (Jun 2015) ISSN: 1532-2742 [Electronic] England
PMID25562448 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • 13-valent pneumococcal vaccine
  • Antibodies, Bacterial
  • Haemophilus Vaccines
  • Pneumococcal Vaccines
  • Vaccines, Conjugate
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial (blood, immunology)
  • Female
  • Haemophilus Vaccines (administration & dosage, immunology)
  • Haemophilus influenzae type b (immunology)
  • Humans
  • Male
  • Middle Aged
  • Neurosurgery
  • Pneumococcal Vaccines (administration & dosage)
  • T-Lymphocytes (immunology)
  • Vaccination
  • Vaccines, Conjugate (administration & dosage, immunology)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: