The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients.
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| Abstract | AIMS: To investigate the association of Sirtuin 3 (SIRT 3) expression between the clinical characteristics and prognosis in breast cancer patients. METHODS: 308 female patients with histologically confirmed breast cancer were enrolled in this study. The SIRT 3 expressions in tumor samples were detected. All the patients were followed up overall survival time (OS) and disease-free survival (DFS) time. RESULTS:
SIRT 3 expression was significantly correlated with clinical characteristics including lymph node metastasis, pathological grade and tumor size of breast cancer. SIRT 3 expression status also affected the DFS and OS of breast cancer. Patients with high expression of SIRT 3 had shorter DFS and OS than those with low expression. Univariate and multivariate Cox analyses confirmed that high SIRT 3 expression predicted a poor prognosis in breast cancer patient. In vitro study revealed that the SIRT 3 knockdown by small interfering RNA technique dramatically reduced the proliferation, migration and invasion of breast cancer cell lines. CONCLUSION: Our results suggest that SIRT 3 may serve as a marker for clinical feature and prognosis for breast cancer.
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| Authors | Shaozhong He, Chun He, Hua Yuan, Shizhong Xiong, Zhenyu Xiao, Longhua Chen |
| Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem) Vol. 34 Issue 6 Pg. 2061-9 ( 2014) ISSN: 1421-9778 [Electronic] Germany |
| PMID | 25562154 (Publication Type: Journal Article) |
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