HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The expression of intermediate filaments in canine mammary glands and their tumors.

Abstract
Monoclonal antibodies specific for different types of intermediate filaments (cytokeratin, vimentin, desmin and neurofilaments) were used to study the histogenesis of canine mammary glands and 57 canine mammary tumors by immunocytochemistry. The intra- and interlobular duct epithelium, acinar, and intralobular myoepithelial cells stained positively for cytokeratin. Peripheral ductal and acinar cells, as well as interstitial cells, stained positively for vimentin. A similar staining pattern was seen in adenomas, complex adenomas, benign mixed tumors, ductular carcinomas, and one myoepithelioma-like tumor. Additionally, cytokeratin positive cells were scattered interstitially in one single adenoma, most complex adenomas, some benign mixed tumors, complex carcinomas, and in the malignant mixed tumors. All stromal cells stained positively for vimentin. The fibrosarcomas were positive only for vimentin, while the following expressed both desmin and cytokeratin: epithelial-like cells in one adenoma, three complex adenomas, the myoepithelioma-like tumor, the single comedo carcinoma, two complex carcinomas, the single lobular carcinoma, one malignant mixed tumor, and three osteosarcomas. Epithelial-like cells in one adenoma, six complex adenomas, two benign mixed tumors, two complex carcinomas, the lobular carcinoma, and the malignant schwannoma stained for neurofilaments. Three tumors, one adenoma, one complex adenoma, and the lobular carcinoma expressed both desmin and neurofilaments in addition to cytokeratin and vimentin. The results show the expression of different types of intermediate filaments and indicate that there might be a stem cell origin in most of the canine mammary tumors.
AuthorsE Hellmén, A Lindgren
JournalVeterinary pathology (Vet Pathol) Vol. 26 Issue 5 Pg. 420-8 (Sep 1989) ISSN: 0300-9858 [Print] United States
PMID2555958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adenoma (analysis, ultrastructure, veterinary)
  • Animals
  • Carcinoma (analysis, ultrastructure, veterinary)
  • Carcinoma, Intraductal, Noninfiltrating (analysis, ultrastructure, veterinary)
  • Cytoskeleton (ultrastructure)
  • Dog Diseases (pathology)
  • Dogs
  • Fibrosarcoma (analysis, ultrastructure, veterinary)
  • Immunohistochemistry
  • Intermediate Filaments (analysis, ultrastructure)
  • Mammary Glands, Animal (ultrastructure)
  • Mammary Neoplasms, Animal (analysis, ultrastructure)
  • Mesenchymoma (analysis, ultrastructure, veterinary)
  • Microscopy, Electron
  • Myoepithelioma (analysis, ultrastructure, veterinary)
  • Neoplasms, Germ Cell and Embryonal (analysis, ultrastructure, veterinary)
  • Osteosarcoma (analysis, ultrastructure, veterinary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: