The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial.

Abstract

The aim of the study is to determine the effect of acute alcohol consumption on enterocytes. Chronic alcohol consumption has been known to induce a decrease in gut wall integrity in actively drinking alcoholics and patients with alcohol-induced liver disease. Data on the extent of the damage induced by acute alcohol consumption in healthy human beings is scarce. Studies show that heavy incidental alcohol consumption is a growing problem in modern society. Data on this matter may provide insights into the consequences of this behavior for healthy individuals. In a randomized clinical trial in crossover design, 15 healthy volunteers consumed water one day and alcohol the other. One blood sample was collected pre-consumption, five every hour post-consumption, and one after 24 h. Intestinal fatty acid binding protein (I-FABP) was used as a marker for enterocyte damage. Liver fatty acid binding protein (L-FABP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) were used as markers for hepatocyte damage. Lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) were used as a measure of translocation. Interleukin-6 (IL-6) was used to assess the acute inflammatory response to endotoxemia. Alcohol consumption caused a significant increase in serum I- and L-FABP levels, compared to water consumption. Levels increased directly post-consumption and decreased to normal levels within 4 h. LBP, sCD14, and IL-6 levels were not significantly higher in the alcohol group. Moderate acute alcohol consumption immediately damages the enterocyte but does not seem to cause endotoxemia.

• Authors: W J de Jong, A M Cleveringa, B Greijdanus, P Meyer, E Heineman, J B Hulscher
• Journal: Alcohol (Fayetteville, N.Y.) (Alcohol) Vol. 49 Issue 1 Pg. 65-70 (Feb 2015) ISSN: 1873-6823 [Electronic] United States
• PMID: 25559494 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• FABP1 protein, human
• Fatty Acid-Binding Proteins
• Ethanol

Topics

• Adolescent
• Adult
• Alcoholic Intoxication (metabolism)
• Cross-Over Studies
• Ethanol (administration & dosage, toxicity)
• Fatty Acid-Binding Proteins (blood)
• Gastrointestinal Tract (drug effects, metabolism)
• Healthy Volunteers
• Humans
• Male
• Single-Blind Method
• Time Factors
• Young Adult