Antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on experimentally induced myocardial infarcted rats.

Abstract

The present study aims to evaluate the antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on isoproterenol-induced hyperlipidaemia and hypertrophy in rats. Rats were pretreated with zingerone (6 mg/kg body weight) daily for a period of 14 days and then induced myocardial infarction with isoproterenol (100 mg/kg body weight) on days 15 and 16. Isoproterenol increased serum creatine kinase and lactate dehydrogenase activities in the rats. Increased levels/concentrations of serum and heart cholesterol and triglycerides were observed in isoproterenol-induced myocardial infarcted rats. Isoproterenol also altered serum lipoproteins and the activity of liver 3-hydroxy-3-methyl glutaryl-coenzyme-A-reductase in the rats. The in vitro study revealed a very convincing reducing power of zingerone. Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy, by virtue of its antihyperlipidaemic, antihypertrophic, and reducing properties in isoproterenol-induced myocardial infarcted rats.

• Authors: K L Hemalatha, P Stanely Mainzen Prince
• Journal: Journal of biochemical and molecular toxicology (J Biochem Mol Toxicol) Vol. 29 Issue 4 Pg. 182-8 (Apr 2015) ISSN: 1099-0461 [Electronic] United States
• PMID: 25558849 (Publication Type: Journal Article)
• Copyright: © 2015 Wiley Periodicals, Inc.

Chemical References

• Hypolipidemic Agents
• Protective Agents
• zingerone
• Guaiacol
• Isoproterenol

Topics

• Animals
• Cardiomegaly (prevention & control)
• Guaiacol (analogs & derivatives, therapeutic use)
• Hyperlipidemias (prevention & control)
• Hypolipidemic Agents (therapeutic use)
• Isoproterenol
• Male
• Myocardial Infarction (chemically induced, drug therapy)
• Protective Agents (therapeutic use)
• Rats
• Rats, Wistar