Abstract | BACKGROUND: Aim was to study the chemiluminescent activity and the activity of NAD- and NADP-dependent dehydrogenases of neutrophils depending on the outcome of the widespread purulent peritonitis (WPP). PATIENTS AND METHODS: 51 patients with a mean age of RSE 54.2 ± 19.2 years were observed. As a control 75 healthy people of similar age range were examined. Lucigenin- and luminol-dependent chemiluminescence activity and activity of NAD(P)-dependent dehydrogenases peripheral blood neutrophils were studied. RESULTS: CONCLUSION: With the reduction of the intensity ofplastic processes and imbalances enzymatic activity in nitrogen metabolism in patients with WPP at unfavorable outcome of the disease increases the activity of enzymes that characterize the level of anaerobic and aerobic respiration. In the absence of marked changes in the activity of enzymes that characterize the level of energy processes in cells of patients with favorable outcome of the WPP, increases the intensity of spontaneous lucigenin-dependent chemiluminescence and reduced neutrophil activation index.
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Authors | A A Savchenko, D É Zdzitovetskiĭ, A G Borisov, N A Luzan |
Journal | Vestnik Rossiiskoi akademii meditsinskikh nauk
(Vestn Ross Akad Med Nauk)
Issue 5-6
Pg. 23-8
( 2014)
ISSN: 0869-6047 [Print] Russia (Federation) |
PMID | 25558676
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- NADH, NADPH Oxidoreductases
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Topics |
- Adult
- Aged
- Enzyme Activation
- Female
- Humans
- Luminescent Measurements
(methods)
- Male
- Middle Aged
- NADH, NADPH Oxidoreductases
(metabolism)
- Neutrophils
(enzymology)
- Peritonitis
(metabolism, therapy)
- Statistics as Topic
- Treatment Outcome
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