[Glanzmann thrombasthenia and pregnancy--report of a case and literature review].

Abstract

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder which deficiency of the platelet glycoprotein IIb - III a. The disorder usually manifests as severe mucocutaneus bleeding in the chaildhood, menstrual patterns in pubertal--adolescent years, rarely life-threatening. Pregnancy and delivery in patients with TG are very rare and are associated with high risk for mother and fetus due to intra - and post-partum hemorrhage. We present a case 30, a patient with TG, emergency births by caesarean section, with intra- and postpartum haemorrhage managed through the use of recombinant factor VIIa, transfusion of packed red blood cells and platelets.

• Authors: E Uchikova, B Pechlivanov, N Parahuleva, G Amaliev
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 53 Issue 5 Pg. 49-51 ( 2014) ISSN: 0324-0959 [Print] Bulgaria
• PMID: 25558673 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Recombinant Proteins
• recombinant FVIIa
• Factor VIIa

Topics

• Adult
• Cesarean Section
• Erythrocyte Transfusion
• Factor VIIa (therapeutic use)
• Female
• Humans
• Platelet Transfusion
• Postpartum Hemorrhage (therapy)
• Pregnancy
• Pregnancy Complications, Hematologic (therapy)
• Recombinant Proteins (therapeutic use)
• Thrombasthenia (therapy)