Abstract |
To synthesize and characterize a novel metal complex of Mn (II) with emodin, and evaluate its anti- cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, (1)H NMR, and (13)C NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG2, HeLa, MCF-7, B16, and MDA-MB-231 was tested by the MTT assay and flow cytometry. Emodin was coordinated with Mn(II) through the 9-C=O and 1-OH, and the general formula of the complex was Mn(II) ( emodin)2·2H2O. In studies of the cytotoxicity, the complex exhibited significant activity, and the IC50 values of the complex against five cancer cell lines improved approximately three-fold compared with those of emodin. The complex could induce cell morphological changes, decrease the percentage of viability, and induce G0/G1 phase arrest and apoptosis in cancer cells. The coordination of emodin with Mn(II) can improve its anticancer activity, and the complex Mn(II) ( emodin)2·2H2O could be studied further as a promising anticancer drug.
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Authors | Li Yang, Jun Tan, Bo-Chu Wang, Lian-Cai Zhu |
Journal | Chinese journal of natural medicines
(Chin J Nat Med)
Vol. 12
Issue 12
Pg. 937-42
(Dec 2014)
ISSN: 1875-5364 [Electronic] China |
PMID | 25556065
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Plant Extracts
- Manganese
- Emodin
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology, therapeutic use)
- Antineoplastic Agents, Phytogenic
(pharmacology, therapeutic use)
- Emodin
(pharmacology, therapeutic use)
- HeLa Cells
- Hep G2 Cells
- Humans
- MCF-7 Cells
- Manganese
(pharmacology, therapeutic use)
- Melanoma, Experimental
(drug therapy)
- Molecular Structure
- Neoplasms
(drug therapy)
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- Polygonaceae
(chemistry)
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