Predictors of long term opioid withdrawal outcome after short-term stabilization with buprenorphine.

Abstract

OBJECTIVE:

We aim to examine predictors of opiate abstinence status 3 months after the end of buprenorphine/naloxone treatment for opioid-dependent participants.

PATIENTS AND METHODS:

Participants (n= 516, age > 15 years) received buprenorphine/ naloxone treatment for 4 weeks and then randomly assigned to undergo dose tapering over either 7 days or 28 days. Bivariate analysis was performed to identify possible predictors of successful opiate abstinence outome (p-value < 0.10). Logistic regression analysis with backward stepwise selection was, then, performed to produce final model containing independent predictors at p-value < 0.05.

RESULTS:

Bivariate analysis identified several possible predictors including: opioid and drug urine tests result at the end taper; employment status, family problems, and alcohol use domains of addiction severity index (ASI) score; and clinical opiate withdrawal scale (COWS) at the end of stabilization. Final predictor list identified by logistic regression include: ASI score for family and alcohol problems, COWS at the end of stabilization and opiate urine test at the end of taper.

CONCLUSIONS:

Participants presenting with a negative urine test for opiate, more severe alcohol, more severe family problems, or more symptoms of opiate withdrawal at the end of stabilization were more likely to have a successful opiate abstinence.

• Authors: M I Saleh
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 18 Issue 24 Pg. 3935-42 ( 2014) ISSN: 2284-0729 [Electronic] Italy
• PMID: 25555887 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Opioid
• Narcotic Antagonists
• Naloxone
• Buprenorphine

Topics

• Adolescent
• Adult
• Aged
• Analgesics, Opioid (therapeutic use)
• Buprenorphine (administration & dosage)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Naloxone (administration & dosage)
• Narcotic Antagonists (administration & dosage)
• Opioid-Related Disorders (drug therapy)
• Substance Withdrawal Syndrome (drug therapy)
• Treatment Outcome
• Young Adult