[The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury].

Abstract

The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin (65 mg/kg) was administered per os 1 h before modeling of ischemia-reperfusion. Studies were carried 1 h after reperfusion. It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion.

• Authors: N Ye Maksimovich, I K Dremza, E I Troian, Ya N Maksimovich, A N Borodinskiĭ
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2014 Nov-Dec Vol. 60 Issue 6 Pg. 643-50 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 25552503 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Lactic Acid
• Pyruvic Acid
• Quercetin
• taxifolin

Topics

• Administration, Oral
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Brain (drug effects, metabolism)
• Brain Ischemia (metabolism, pathology, prevention & control)
• Lactic Acid (metabolism)
• Mitochondria (drug effects, metabolism, pathology)
• Oxidative Stress
• Oxygen Consumption (drug effects)
• Pyruvic Acid (metabolism)
• Quercetin (analogs & derivatives, pharmacology)
• Rats
• Reperfusion Injury (metabolism, pathology, prevention & control)