A novel use for botulinum toxin A in the management of ileostomy and urostomy leaks.

Abstract

PURPOSE:

To assess the efficacy of Botulinum toxin A (BoNT-A) in the treatment of patients with hypercontractile stomas resulting in repeated pouching system failures and leaks.

DESIGN:

Prospective case series.

SUBJECTS AND SETTING:

Ten consecutive patients who presented to the outpatient stoma clinic with actively contractile stomas that shortened spasmodically resulting in leaks were offered treatment with BoNT-A if treatment with other measures had been unsuccessful.

METHODS:

Following an observed reduction in the peristalsic shortening of a stoma after intradermal injection of BoNT-A for hyperhidrosis, we conducted a prospective case series of 10 patients with pouch adhesive failures attributed to spasmodic shortening of the stoma. Ten patients, 3 with urostomies and 7 with ileostomies, were offered BoNT-A injection. The first was treated cautiously with 15 units of BoNT-A injected into the muscularis layer, followed by an additional 25 units injected 1 month later. Subsequent patients received doses varying from 50 to 100 units. Ongoing treatments ranged 50 to 100 units every 3 to 6 months.

RESULTS:

Seventy percent (n = 7) of patients reported a useful reduction in leakage and pouching system seal failures. In these 7 patients, the frequency of pouch changes changed from an average of 2.18 to 0.44 per day (over all 10 patients this was a change from an average of 2.35 per day to 1.16 per day). No adverse side effects were reported.

CONCLUSION:

Findings from this clinical case series suggest that BoNT-A may be a promising treatment in the management of patients with leaks caused by actively contracting stomas.

• Authors: Vanessa M Smith, Calum C Lyon
• Journal: Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society (J Wound Ostomy Continence Nurs) 2015 Jan-Feb Vol. 42 Issue 1 Pg. 83-8 ISSN: 1528-3976 [Electronic] United States
• PMID: 25549312 (Publication Type: Journal Article)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (adverse effects, drug effects, therapeutic use)
• Humans
• Ileostomy (nursing)
• Injections, Intradermal
• Neuromuscular Agents (pharmacology, therapeutic use)
• Surgical Stomas (adverse effects)
• Treatment Outcome