Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study.

Abstract

Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.

• Authors: Hayder M Alkuraishy, Ali I Al-Gareeb, Ali K Albuhadilly
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 324307 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25548768 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Blood Proteins
• Vinca Alkaloids
• vinpocetine
• Pyrithioxin

Topics

• Aged
• Blood Proteins (biosynthesis)
• Blood Viscosity (drug effects)
• Cerebrovascular Disorders (blood, drug therapy, physiopathology)
• Drug Synergism
• Erythrocytes
• Female
• Humans
• Male
• Middle Aged
• Pyrithioxin (administration & dosage)
• Randomized Controlled Trials as Topic
• Rheology
• Vinca Alkaloids (administration & dosage)