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Impact of routine methicillin-resistant Staphylococcus aureus (MRSA) surveillance and cohorting on MRSA-related bloodstream infection in neonatal intensive care unit.

AbstractOBJECTIVE:
To study the impact of methicillin-resistant Staphylococcus aureus (MRSA) surveillance on the incidence of MRSA-related bloodstream infection (BSI) in neonatal intensive care unit (NICU) and to evaluate cost-effectiveness of MRSA surveillance.
STUDY DESIGN:
MRSA surveillance policy was introduced in our NICU in April 2008. Pre-MRSA surveillance period (P1, April 2006-March 2008) was compared with the surveillance period (P2, April 2008-April 2010) for MRSA-related BSI (MRSA BSI).
RESULTS:
During P1 and P2, 1,576 and 1,512 neonates were enrolled. Of these, 3.8/1,000 and 5.3/1,000 developed MRSA BSI, respectively. During P2, 100% MRSA-related BSI occurred in MRSA-colonized neonates, as compared with zero in noncolonized group (p < 0.0001). Overall, 7 (30%) of the 23 neonates colonized during hospitalization developed MRSA BSI as compared with 1 of the 31 (3%) neonates colonized at admission (p = 0.007). Direct screening cost was $208 per patient. Since 28 neonates had to be screened to detect one colonization, $5,824 estimated per detection, excluding indirect costs.
CONCLUSIONS:
MRSA surveillance may protect non-MRSA colonized neonates from becoming colonized. This is of considerable importance because the acquisition of colonization during hospitalization was associated with a 10-fold increase in risk of developing MRSA BSI. Cost-effectiveness of MRSA surveillance remains debatable and further studies are needed to delineate cost-benefit ratio.
AuthorsAshlesha Kaushik, Helen Kest, Adel Zauk, Vincent A DeBari, Michael Lamacchia
JournalAmerican journal of perinatology (Am J Perinatol) Vol. 32 Issue 6 Pg. 531-6 (May 2015) ISSN: 1098-8785 [Electronic] United States
PMID25545444 (Publication Type: Journal Article)
CopyrightThieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Topics
  • Bacteremia (epidemiology)
  • Cross Infection (epidemiology)
  • Female
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • Male
  • Methicillin-Resistant Staphylococcus aureus (isolation & purification)
  • Neonatal Screening (economics)
  • Staphylococcal Infections (epidemiology)

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