[Research advances on caspase-independent cell death of K562 cells].

Abstract

Caspase independent cell death (CICD) is defined as death that ensues when a signal that normally induces apoptosis fails to activate caspases,it can be activated by PARP-1, Calpains, Bax and AIF, possessing distinctive biologic characteristic differed from apoptosis and necrosis. Recent researchs have found that the molecular mechanisms governing CICD of K562 is opposite from that of the traditional medicine killing leukemia cells, which may have the potential pharmaceutical point for new drugs. This article reviews the newly acquaintance of molecular mechanisms for CICD and recent studies concerning the induction death of K562 cells via CICD, so as to provide some reference for the research of new drug point.

• Authors: Fei Xin, Wu Wei
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 22 Issue 6 Pg. 1780-4 (Dec 2014) ISSN: 1009-2137 [Print] China
• PMID: 25543516 (Publication Type: Journal Article, Review)

Chemical References

• bcl-2-Associated X Protein
• Poly(ADP-ribose) Polymerases
• Calpain
• Caspases

Topics

• Apoptosis
• Calpain
• Caspases
• Humans
• K562 Cells
• Necrosis
• Poly(ADP-ribose) Polymerases
• bcl-2-Associated X Protein