Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy.

Abstract

By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5/PEG nanocomposites. The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5/PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5/PEG and the following 808-nm laser irradiation (0.5 W/cm(2)). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5/PEG in mice after treatment. These results indicate potential application of GO/BaGdF5/PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.

• Authors: Hao Zhang, Huixia Wu, Jun Wang, Yan Yang, Dongmei Wu, Yingjian Zhang, Yang Zhang, Zhiguo Zhou, Shiping Yang
• Journal: Biomaterials (Biomaterials) Vol. 42 Pg. 66-77 (Feb 2015) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 25542794 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Barium Compounds
• Oxides
• Solutions
• Barium
• Polyethylene Glycols
• Graphite
• Gadolinium
• Fluorides

Topics

• Animals
• Barium (pharmacology)
• Barium Compounds (pharmacology)
• Cell Death (drug effects)
• Fluorides (pharmacology)
• Gadolinium (pharmacology)
• Graphite (pharmacology)
• HeLa Cells
• Humans
• Hyperthermia, Induced
• Magnetic Resonance Imaging
• Mice
• Mice, Nude
• Multimodal Imaging
• Nanocomposites (chemistry, ultrastructure)
• Neoplasms (pathology)
• Oxides (pharmacology)
• Phototherapy
• Polyethylene Glycols (chemistry)
• Solutions
• Spectroscopy, Fourier Transform Infrared
• Spectroscopy, Near-Infrared
• Tomography, X-Ray Computed
• X-Ray Diffraction