[Comparison of blood flow and benzodiazepine receptor distribution in focal epilepsy: preliminary results of a SPECT study].

Abstract

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT.2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz-receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123I-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

• Authors: P Bartenstein, A Ludolph, O Schober, G Lottes, I Böttger, H F Beer
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 28 Issue 5 Pg. 181-6 (Oct 1989) ISSN: 0029-5566 [Print] Germany
• Vernacular Title: Vergleich von Blutfluss und Benzodiazepin-Rezeptor-verteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie.
• PMID: 2554260 (Publication Type: Journal Article)

Chemical References

• Receptors, GABA-A

Topics

• Adult
• Aged
• Brain (diagnostic imaging)
• Brain Mapping
• Epilepsies, Partial (diagnostic imaging)
• Female
• Humans
• Male
• Middle Aged
• Radioligand Assay
• Receptors, GABA-A (analysis)
• Tomography, Emission-Computed, Single-Photon