Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland.

Abstract

BACKGROUND/AIM:

To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics.

MATERIALS AND METHODS:

A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test.

RESULTS:

P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, P63, and P73 proteins was not associated with age, sex, or lymph node metastasis (P > 0.05). Expression of P53 and P73 proteins, instead of the P63 protein, was correlated to the degree of malignancy (P = 0.026 and 0.018, respectively). There was no significant difference among the P53, P73, and P63 proteins in malignant parotid gland tumors (P > 0.05). In the follow-up, only one patient died of colon cancer.

CONCLUSION:

Our results suggest that the P53, P63, and P73 proteins may play a role in the development of malignant parotid gland tumors and provide data for their diagnosis.

• Authors: Mei Yong, Ling Yang, Qimuge Suyila, Wenyan Han, Hongwei Yuan, Cheng Zhao, Xiulan Su
• Journal: Turkish journal of medical sciences (Turk J Med Sci) Vol. 44 Issue 5 Pg. 875-82 ( 2014) ISSN: 1300-0144 [Print] Turkey
• PMID: 25539561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Binding Proteins
• Nuclear Proteins
• TP63 protein, human
• TP73 protein, human
• Transcription Factors
• Tumor Protein p73
• Tumor Suppressor Proteins

Topics

• Adenocarcinoma (metabolism)
• Adult
• Aged
• Carcinoma, Adenoid Cystic (metabolism)
• DNA-Binding Proteins (metabolism)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Mucoepidermoid Tumor (metabolism)
• Nuclear Proteins (metabolism)
• Parotid Neoplasms (metabolism)
• Transcription Factors (metabolism)
• Tumor Protein p73
• Tumor Suppressor Proteins (metabolism)
• Young Adult