Abstract | OBJECTIVE:
Catestatin has several cardiovascular actions, in addition to diminished sympatho-adrenal flow. Decreased plasma catestatin levels may reflect a predisposition for the development of hypertension and metabolic disorders. We planned to investigate the possible roles of catestatin in untreated hypertensive patients. As a secondary objective, we compared catestatin concentrations of healthy subjects with those of hypertensive patients in order to understand whether catestatin is increased reactively or diminished at onset. METHODS: Our study was cross-sectional and observational. The patient group, comprising 109 consecutive untreated hypertensive patients without additional systemic or coronary heart disease, underwent evaluations of plasma catestatin, waist circumference, lipid parameters, left ventricular mass, carotid intima-media thickness, and flow-mediated dilation of the brachial artery. Additionally, we measured catestatin concentrations of 38 apparently healthy subjects without any disease using a commercial enzyme-linked immunosorbent assay kit. RESULTS: We documented increased catestatin concentrations in previously untreated hypertensive patients compared to healthy controls (2.27±0.83 vs. 1.92±0.49 ng/mL, p=0.004). However, this association became insignificant after adjustments for age, gender, height, and weight. Within the patient group, catestatin levels were significantly higher in females. Among all study parameters, age, high-density lipoprotein cholesterol (HDL-C) correlated positively to plasma catestatin, whereas triglycerides, hemoglobin, and left ventricular mass correlated negatively to plasma catestatin. We could not detect an association between vascular parameters and catestatin. Catestatin levels were significantly elevated with increasing HDL-C (1.91±0.37, 2.26±0.79, and 3.1±1.23 ng/mL in patients with HDL-C <40, 40-60, and >60 mg/dL, respectively). Multiple linear regression analysis revealed age (beta: 0.201, p=0.041) and HDL-C (beta: 0.390, p<0.001) as independent correlates of plasma catestatin concentration. Additionally, male gender (beta:-0.330, p=0.001) and plasma catestatin (beta: 0.299, p=0.002) were significantly associated with HDL-C concentrations. CONCLUSION:
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Authors | Murtaza Emre Durakoğlugil, Teslime Ayaz, Sinan Altan Kocaman, Aynur Kırbaş, Tuğba Durakoğlugil, Turan Erdoğan, Mustafa Çetin, Osman Zikrullah Şahin, Yüksel Çiçek |
Journal | Anatolian journal of cardiology
(Anatol J Cardiol)
Vol. 15
Issue 7
Pg. 577-85
(Jul 2015)
ISSN: 2149-2271 [Electronic] Turkey |
PMID | 25538000
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Cholesterol, HDL
- Chromogranin A
- Peptide Fragments
- Triglycerides
- chromogranin A (344-364)
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Topics |
- Adult
- Anthropometry
- Cholesterol, HDL
(blood)
- Chromogranin A
(blood)
- Cross-Sectional Studies
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Linear Models
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Triglycerides
(blood)
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