HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Side-to-Side Jejunoileal Bypass Induces Better Glucose-Lowering Effect than End-to-Side Jejunoileal Bypass on Nonobese Diabetic Rats.

AbstractBACKGROUND:
Jejunoileal bypass (JIB) can markedly ameliorate diabetes in obese patients and rodents. The aim of this study is to systematically evaluate the role of the operational manner and the retained distal small bowel length in mediating changes in glucose homeostasis after intestinal bypass surgeries in nonobese diabetic rats.
METHODS:
Streptozotocin-induced diabetic rats underwent side-to-side jejunoileal bypass plus proximal loop ligation (SSJIBL), end-to-side jejunoileal bypass (ESJIB), proximal small bowel resection (PBR), and sham operation. Each operational manner included two subgroups, in which 30 cm (L-30) or 40 cm (L-40) distal small bowel was retained. Main outcome measures were fasting blood glucose levels (FBG), insulin sensitivity, serum insulin, glucagon-like peptide-1 (GLP-1), bilirubin (BIL), and total bile acids (TBA) levels.
RESULTS:
Global food intake in the sham group was higher than in the operation groups, and global body weight and food intake in the SSJIBL group were higher than in the ESJIB and PBR groups. Global body weight and food intake in L-40 group were higher than in L-30 group. The SSJIBL procedure induced better improvement in glucose homeostasis and insulin sensitivity than the ESJIB and PBR procedures, and L-30 group showed better antidiabetic effects than L-40 group. Serum GLP-1, BIL, and TBA levels in SSJIBL group were higher than in ESJIB and PBR groups.
CONCLUSIONS:
This study shows that side-to-side jejunoileal bypass induced better glucose-lowering effects than end-to-side jejunoileal bypass and proximal small bowel resection, and intestinal bypass surgery that retained shorter distal small bowel yielded better antidiabetic effects.
AuthorsJinyuan Duan, Cai Tan, Hang Xu, Shaolin Nie
JournalObesity surgery (Obes Surg) Vol. 25 Issue 8 Pg. 1458-67 (Aug 2015) ISSN: 1708-0428 [Electronic] United States
PMID25537298 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Streptozocin
  • Glucagon-Like Peptide 1
Topics
  • Anastomosis, Surgical (methods)
  • Animals
  • Blood Glucose (metabolism)
  • Diabetes Mellitus, Experimental (blood, chemically induced, complications, surgery)
  • Down-Regulation
  • Eating (physiology)
  • Glucagon-Like Peptide 1 (blood)
  • Intestine, Small (surgery)
  • Jejunoileal Bypass (methods)
  • Male
  • Obesity (blood, complications, surgery)
  • Rats
  • Rats, Sprague-Dawley
  • Streptozocin

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: