Abstract | BACKGROUND:
Jejunoileal bypass (JIB) can markedly ameliorate diabetes in obese patients and rodents. The aim of this study is to systematically evaluate the role of the operational manner and the retained distal small bowel length in mediating changes in glucose homeostasis after intestinal bypass surgeries in nonobese diabetic rats. METHODS: RESULTS: Global food intake in the sham group was higher than in the operation groups, and global body weight and food intake in the SSJIBL group were higher than in the ESJIB and PBR groups. Global body weight and food intake in L-40 group were higher than in L-30 group. The SSJIBL procedure induced better improvement in glucose homeostasis and insulin sensitivity than the ESJIB and PBR procedures, and L-30 group showed better antidiabetic effects than L-40 group. Serum GLP-1, BIL, and TBA levels in SSJIBL group were higher than in ESJIB and PBR groups. CONCLUSIONS:
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Authors | Jinyuan Duan, Cai Tan, Hang Xu, Shaolin Nie |
Journal | Obesity surgery
(Obes Surg)
Vol. 25
Issue 8
Pg. 1458-67
(Aug 2015)
ISSN: 1708-0428 [Electronic] United States |
PMID | 25537298
(Publication Type: Journal Article)
|
Chemical References |
- Blood Glucose
- Streptozocin
- Glucagon-Like Peptide 1
|
Topics |
- Anastomosis, Surgical
(methods)
- Animals
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Experimental
(blood, chemically induced, complications, surgery)
- Down-Regulation
- Eating
(physiology)
- Glucagon-Like Peptide 1
(blood)
- Intestine, Small
(surgery)
- Jejunoileal Bypass
(methods)
- Male
- Obesity
(blood, complications, surgery)
- Rats
- Rats, Sprague-Dawley
- Streptozocin
|