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A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection.

AbstractOBJECTIVES:
This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection.
METHODS:
Forty-five patients were divided into 3 treatment groups. Skin cooling with ethyl chloride spray (in group 1), topical anesthetic cream (EMLA) (in group 2), was used on the forehead area on one side previous to injection; the opposite side served as the control. In the third group (n = 15), cold was applied using ethyl chloride spray to one side, and to the other side topical anesthetic cream (EMLA) was applied. A visual analog scale was used for pain intensity.
RESULTS:
In the first group, the average pain score was 3.20 ± 1.20 on the side where ethyl chloride spray was applied and 7.26 ± 1.94 on the control side (P < 0.05). It was 4.20 ± 1.37 on the side receiving EMLA and 7.66 ± 1.54 (P < 0.05) on the control side in the second group. In the third group, the average score was 6.80 ± 1.37 for the EMLA side and 2.93 ± 1.03 for the ethyl chloride sprayed side (P < 0.05).
CONCLUSIONS:
Skin cooling with ethyl chloride spray significantly decreases the pain associated during forehead botulinum toxin injections.
AuthorsSaime Irkoren, Heval Selman Ozkan, Huray Karaca
JournalAnnals of plastic surgery (Ann Plast Surg) Vol. 75 Issue 3 Pg. 272-4 (Sep 2015) ISSN: 1536-3708 [Electronic] United States
PMID25536197 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Acetylcholine Release Inhibitors
  • Aerosols
  • Anesthetics, Local
  • Lidocaine, Prilocaine Drug Combination
  • Prilocaine
  • Ethyl Chloride
  • Lidocaine
  • Botulinum Toxins, Type A
Topics
  • Acetylcholine Release Inhibitors (administration & dosage, adverse effects)
  • Adult
  • Aerosols
  • Anesthetics, Local (therapeutic use)
  • Botulinum Toxins, Type A (administration & dosage, adverse effects)
  • Cosmetic Techniques (adverse effects)
  • Cross-Over Studies
  • Ethyl Chloride (therapeutic use)
  • Female
  • Forehead
  • Humans
  • Injections, Subcutaneous
  • Lidocaine (therapeutic use)
  • Lidocaine, Prilocaine Drug Combination
  • Middle Aged
  • Pain (chemically induced, diagnosis, drug therapy)
  • Pain Measurement
  • Prilocaine (therapeutic use)
  • Prospective Studies
  • Skin Cream
  • Treatment Outcome

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